Depression- and Anxiety-like Behaviors in Cisplatin-treated Rats: Effects of Curcumin (#875)
Cisplatin is a highly effective chemotherapeutic agent against solid tumor (1); however, side-effects and drug resistance are the limiting factors for its use. Curcumin, active ingredient of turmeric, has been previously shown to have additive effects in the cisplatin chemotherapy (2-4). In the present study, we investigated behavioral effects of the co-administration of cisplatin and curcumin. To this purpose, thirty-four adult male Wistar rats were recruited and divided into four groups as follows: Control (n=7; received 0.9 % saline/week, i.p. and corn oil/day, p.o.), Curcumin (n=7; received 0.9 % saline/week, i.p. and 300 mg/kg/day, p.o. curcumin), Cisplatin (n=10; received 5 mg/kg/week, i.p. cisplatin and corn oil/day, p.o.), and Curcumin plus Cisplatin (n=10; received 5 mg/kg/week, i.p. cisplatin and 300 mg/kg/day, p.o. curcumin). The treatments were continued for 5 weeks. The animals were subjected to the open field, elevated plus maze, and forced swim tests to evaluate depression- and anxiety-like behaviors. According to our results, we found that neither cisplatin nor curcumin administration resulted in a behavioral impairment. Also, the co-administration of cisplatin and curcumin was found to be safe and well-tolerated in terms of mood-related behaviors. Therefore, we deduced that curcumin does not interact with cisplatin to disturb the behavioral neurophysiology.
- Albers J, Chaudhry V, Cavaletti G, et al. (2007). Interventions for preventing neuropathy caused by cisplatin and related compounds. Cochrane Database Syst Rev, (1), pCD005228.
- Fetoni AR, Eramo, Sara L M, Paciello F, et al. (2014). Curcuma longa (curcumin) decreases in vivo cisplatin-induced ototoxicity through heme oxygenase-1 induction. Otol Neurotol, 35, e169-77.
- Mendonça LM, da Silva Machado, Carla, Correia Teixeira, Cristiane Cardoso, et al. (2013). Curcumin reduces cisplatin-induced neurotoxicity in NGF-differentiated PC12 cells. NeuroToxicology, 34, 205–11.
- Ueki M, Ueno M, Morishita J, et al. (2013). Curcumin ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice. J Biosci Bioeng, 115, 547–51.